A.19.CN:8.3 - Clinical/episteme line — Trial‑outcome CN‑frame (Cardio_2026)

• cs_basis:
  • slot_id: ΔBP characteristic: BloodPressureChange scale: { type: ratio, unit: mmHg } polarity: down
  • slot_id: AdverseRate characteristic: AdverseEventRate scale: { type: ratio, unit: “%” } polarity: down
  • slot_id: Age characteristic: Age scale: { type: ratio, unit: years } polarity: neutral
• chart: cohort definition; MethodDescription#TrialProtocol_v5
• normalization: case‑mix adjustment (propensity score); invariant = adjusted ΔBP
• comparability: normalization‑based (UNM) (post‑adjustment)
• aggregation: recombine subcohorts only under the declared population and weighting model; select the law or supported bound for each named safety outcome under its own justified dependency model.
• RSG hook: evidence-use validation of an admission requires CN‑frame acceptance; Assurance pulls CL from any Bridge used.