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Library / First Principles Framework (FPF) - Core Conceptual Specification
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Source changed 2026-10-03 11:52:20 UTC · snapshot created 2026-10-03 11:53:41 UTC · last check 2026-10-03 14:35:13 UTC

C.2.P.DR:5.8 - CRISPR guide-selection table

Wording: “The guide-selection table approves the edit.”

Repair:

DeclarativeRepresentationRepair:
  VisibleExpressionOrArtifact: CRISPR guide-selection table with off-target scores and candidate ranking
  CurrentDirectObjectOrRelation: candidate-guide comparison and exact characteristic values under C.16 or A.19; use A.10 to recover any independently established direct support relation needed for reliance
  RepresentationOrCorrespondenceUse: proposed correspondence from this table's candidate and off-target-score representation elements to the exact candidate-guide comparison and exact characteristic values named above; C.29 lens-use account not yet supplied
  SourceOrPublicationRelation: none
  TemptingStrongerActionClaim: ranked row approves biological intervention
  RecoveredGoverningPattern: C.16 or A.19 for characteristics when current; A.10 for evidence; A.15.2 for experimental work plan; A.21 or authority pattern only if approval or gate claim is current
  RetainedUse: source-finding, candidate comparison, and constraint review
  BlockedStrongerActionClaim: no edit approval, work occurrence, safety claim, or gate passage from table rank alone
  StopOrReopenCondition: recover or cite a C.29 lens-use account that states the preserved and lost structure and bounds the intended use; until then this representation branch is an incomplete rewrite, and claim-bearing use of the proposed correspondence is blocked; reopen when protocol, gate decision, evidence path, lab classification or assignment, exact GrantedPermissionRelation@Context or direct authority result, or dated lab Work becomes current; unresolved “role authorization” goes to E.10.ROLE, and an unsupported stronger permission or authority claim returns missing-governor

A lab notebook, protocol publication, source episteme, and review record remain separate objects. State an exact source or publication relation and its participants only when it obtains; none of these objects belongs in SourceOrPublicationRelation by mention alone.