MMP.16:2 - Problem
A model can predict a large difference that the actual record cannot show. An instrument may saturate, a log may aggregate away timing, or an unknown offset may account for the apparent difference. Conversely, overlapping distributions can still support a useful distinction; requiring one observation to identify the model without error can reject worthwhile designs.
An observation can also be highly informative about something irrelevant to the requested result. Choosing a design by parameter uncertainty, fit or model label can therefore direct effort away from the question that made the modeling useful.
The problem is to construct a feasible observation whose possible records support a consequential comparison, with the uncertainty and cost that this use can tolerate.